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The likelihood that two proteins interact might depend on the proteins' age

Nature Precedings

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Title The likelihood that two proteins interact might depend on the proteins' age
 
Date 2007-01-22T19:19:46Z
 
Creator Pedro Beltrao
 
Subject Bioinformatics
Evolutionary Biology
 
Description It has been previously shown [1] that _S. cerevisiae_ proteins preferentially interact with proteins of the same estimated likely time of origin. To study this observation further, the protein interaction networks of _S. cerevisiae_ and _H. sapiens_ were analyzed taking into account an estimate for the age of the proteins in these species. These estimates were obtained by studying the presence and absence of putative orthologs in other eukaryotic species. In this work preliminary results are described that point to a dependence of the likelihood of protein interaction on the proteins 19; age. The probability of two proteins interactions was found to be linearly dependent on the time the proteins have co-existed in the species.
 
Identifier http://precedings.nature.com/documents/22/version/1
oai:nature.com:10.1038/npre.2007.22.1
http://dx.doi.org/10.1038/npre.2007.22.1
 
Source Nature Precedings
 
Type Manuscript
 
Rights Creative Commons Attribution 3.0 License