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Communication between bone marrow niches in normal bone marrow function and during hemopathies progression

Hematology Reports

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Title Statement Communication between bone marrow niches in normal bone marrow function and during hemopathies progression
Added Entry - Uncontrolled Name Sara Lamorte; Portuguese Institute of Oncology, Lisbon, Portugal
Leonor Remédio; Portuguese Institute of Oncology, Lisbon, Portugal
Sergio Dias; Portuguese Institute of Oncology, Lisbon, Portugal
Associação Portuguesa Contra a Leucemia; Liga Portuguesa Contra o Cancro
Uncontrolled Index Term Medicine;Hematology;
bone marrow niches, hematopoietic stem cells properties, molecular signals
Summary, etc. Hematopoietic stem cell (HSC) chemotaxis, adhesion, proliferation, quiescence and differentiation are regulated by interactions with bone marrow (BM) niches. Two niches have been identified in the adult BM: the endosteal (close to the bone) and the perivascular niche (close to blood vessels). A vast body of literature has revealed the molecular basis for the interaction of HSCs with the two niches. However, the signals that regulate the communication between the two niches have not been well defined. Taking in consideration several clinical and experimental arguments this review highlights the molecular cues, involved in the communication between the BM niches, which regulate the basic properties of HSCs in physiological and malignant conditions. As such, it aims at clarifying the most important advances in basic and clinical research focusing on the role of different factors in the regulation of the BM microenvironment.
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Data Source Entry Hematology Reports; Vol 1, No 2 (2009); e14
Language Note en
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