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Histone deacetylase inhibitors in multiple myeloma

Hematology Reports

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Authentication Code dc
Title Statement Histone deacetylase inhibitors in multiple myeloma
Added Entry - Uncontrolled Name Sarah Deleu
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Els Van Valckenborgh
Ben Van Camp
Joanna Fraczek
Isabelle Vande Broek
Vera Rogiers
Karin Vanderkerken
Uncontrolled Index Term Multiple myeloma; Epigenetics; HDAC inhibitors
Summary, etc. Novel drugs such as bortezomib and high dose chemotherapy combined with stem cell transplantation improved the outcome of multiple myeloma patients in the past decade. However, multiple myeloma often remains incurable due to the development of drug resistance governed by the bone marrow micro-environment. Therefore targeting new pathways to overcome this resistance is needed. Histone deacetylase (HDAC) inhibitors represent a new class of anti-myeloma agents. Inhibiting HDACs results in histone hyperacetylation and alterations in chromatine structure, which, in turn, cause growth arrest differentiation and/or apoptosis in several tumor cells. Here we summarize the molecular actions of HDACi as a single agent or in combination with other drugs in different in vitro and in vivo myeloma models and in (pre)clinical trials.
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Data Source Entry Hematology Reports; Vol 1, No 1 (2009); e9
Language Note en
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